California Gov. Brown vetoes several key bills, signs others; medical patients hit the hardest

If you live in California, click here to support access on school grounds and tax breaks for donated cannabis. 

Gov. Jerry Brown recently acted on a raft of cannabis bills that passed this year. Here is a quick breakdown of what was signed and what was vetoed.

 

Among the bills signed into law:
  • AB 1793 allows adults convicted of cannabis-related offenses that are no longer considered illegal to have them automatically removed from their records.
  • SB 1294 creates equity provisions that will allow cannabis business licensees who qualify to get access to low- or no-interest loans and grants.
  • AB 2215 requires the Veterinary Medical Board to establish guidelines for licensed veterinarians to discuss the use of cannabis on animals.
  • AB 2020 allows cannabis to be sold and consumed at special events.
Unfortunately, Gov. Brown vetoed several important bills:
  • SB 1127 would allow medical cannabis to be administered on school property for registered patients.
  • SB 829 would exempt cannabis from taxes when donated free of charge to dispensaries for their low-income patients.
  • SB 1863 would allow licensed cannabis companies to deduct standard business expenses under the state’s personal income tax.
Lawmakers are now considering whether they have the two-thirds votes to override the vetoes. Click here to send a message to your lawmakers in support of tax breaks for cannabis donated to needy patients and protections for medical cannabis patients at schools.

 

Cannabis policy made big strides this year, but there is more to do. Please forward this message to family, friends, and allies in California!

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Analysis: Michigan legalization measure would generate $520 million in new tax revenue over five years

A recent study of the potential fiscal impacts of legalizing marijuana in Michigan found that passage of Prop 1 would generate over half a billion dollars in additional revenue for the state in the first five years of implementation. Read local coverage of the analysis here.

Much of the revenue generated from marijuana would be directed to Michigan’s roads, schools, and local communities, which are currently underfunded.

The report, conducted by marijuana policy consulting firm VS Strategies, made predictions based on a model that drew upon analysis of multiple data sources. By 2023, the study predicts that total annual marijuana sales will exceed $800 million in Michigan. Read the detailed findings of the analysis here.

Election Day is just over a month away, and voters will soon be receiving absentee ballots. There’s not much time left, and the YES on 1 campaign needs your help to ensure the measure passes. Chip in with a contribution today to help them dispel the fear tactics and propaganda of their prohibitionist opponents.

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How Many Grams Are in an Ounce of Marijuana

When purchasing cannabis, an ounce is a common quantity – especially among regular consumers. But how many grams are in an ounce of marijuana?

When it comes to purchasing marijuana, an ounce is often considered the holy grail.  It’s not the largest quantity you can purchase, but it represents an amount large enough to actually last a while, even for heavy consumers. When it comes to the marijuana market, an ounce of marijuana is 28 grams. However, technically speaking an ounce of marijuana is 28.34 grams.

The same barely-noticeable discrepancy is true of all other typical forms of marijuana quantities that are sold. For example:

  • 1/8 an ounce = 3.54 grams
  • 1/4 an ounce = 7.08 grams
  • 1/2 an ounce = 14.17 grams
  • 1 ounce = 28.34 grams

Below is a visual comparison of these quantities, provided by Leafly:

 

In addition to the standard one gram, these four quantities will all be an option when purchasing marijuana; this is true whether purchasing from a dealer or a legal cannabis retail outlet. Some offer smaller amounts, such as half grams, but that has become more uncommon in recent years.

Other quantities of marijuana:

The quantities shown in the image above are the most common when it comes to marijuana. However, some like to purchase even larger amounts. Here are some of those options:

Quarter pound of marijuana:

A quarter pound of marijuana is the same as four ounces. Given that most legal states have a limit of 2.5 ounces of less, purchasing a quarter pound or more at one time is typically relegated to the black market. A quarter pound equals:

  • 32 eights
  • 112 grams

Half pound of marijuana:

A half pound of marijuana is the same as eight ounces. A half pound equals:

  • 64 eights
  • 224 grams

Full pound of marijuana:

A full pound of marijuana is the same as 16 ounces. A full pound equals:

    • 128 eights

President Trump’s Marijuana Grade

If grading President Trump strictly in regards to marijuana and marijuana laws, what score would he get? Here we give our take.

Say what you will about President Trump – and most people would happily do so all day if asked, whether they support or oppose him – he’s made moves that have surprised many supporters of marijuana law reform, while simultaneously giving mixed messages on the issue.

Below we list the pros and  cons of Trump’s presidency as it relates to marijuana, and then give him a final grade (again, strictly on this subject).

Pros:

  • Earlier this year Trump teamed with Senator Cory Gardner (R) in announcing that he supports state rights when it comes to marijuana legalization laws, and said he will support future legislation to change the law to ensure that the feds won’t interfere with state marijuana laws. In doing so, Trump went beyond recent presidents in supporting the marijuana reform movement (in fact, both Presidents Bush and Obama spent vast amount of resources raiding state-legal medical marijuana dispensaries).
  • Trump has stated on numerous occasions, including during his presidential campaign, that he’s “100%” in support of medical marijuana. This isn’t the same for recreational marijuana, but is still a positive.
  • For the most part, Trump has avoided the anti-marijuana rhetoric perpetuated by many Republican lawmakers. It’s hard to list not doing something ridiculous as a pro, but given the landscape we will.

 

Cons:

  • Trump chose then-Senator Jeff Sessions as his attorney general. Sessions is known for spending decades opposing marijuana and any liberalization of the laws surrounding it, and has actively pushed for an expansion of the war on drugs. If it wasn’t for the Sessions  pick, Trump’s grade would be considerably higher.
  • Other than the Gardner deal, Trump has done nothing to actively support a reformation of marijuana laws – and even the Gardner deal was done in large part because he was blocking

Study: CBD-Rich Cannabis Extracts Present “a Better Therapeutic Profile” Than Pure CBD

CBD-rich extracts which contain at least a small amounts of other cannabinoids “present a better therapeutic profile” than CBD alone, according to a new study published by the journal Frontiers in Neurology.

Cannabis oil (photo: David Downs).

The study, titled Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy, states that the improved benefits of high-CBD cannabis extracts over pure CBD “is likely due to synergistic effects of CBD with other phytocompounds (aka Entourage effect)”.

According to the study’s abstract. “This meta-analysis paper describes the analysis of observational clinical studies on the treatment of refractory epilepsy with cannabidiol (CBD)-based products. Beyond attempting to establish the safety and efficacy of such products, we also investigated if there is enough evidence to assume any difference in efficacy between CBD-rich extracts compared to purified CBD products.”

Researchers state that “the systematic search took place in February/2017 and updated in December/2017 using the keywords “epilepsy” or “Dravet” or “Lennox-Gastaut” or “CDKL5” combined with “Cannabis,” “cannabinoid,” “cannabidiol,” or “CBD” resulting in 199 papers. The qualitative assessment resulted in 11 valid references”.

The categorical data of a total of 670 patients were analyzed by Fischer test. The average daily dose ranged between 1 and 50 mg/kg, with treatment length from 3 to 12 months (mean 6.2 months).

“Two thirds of patients reported improvement in the frequency of seizures (399/622, 64%)”, states the study. “There were more reports of improvement from patients treated with CBD-rich extracts (318/447, 71%) than patients treated with purified CBD (81/223, 36%), with statistical significance.”

Nevertheless, “when the standard clinical threshold of a “50% reduction or more in the frequency of seizures” was applied, only 39% of the individuals were considered “responders,” and there was no difference between treatments with CBD-rich extracts (97/255, 38%) and purified CBD (94/223, 42%).”

Patients treated with CBD-rich extracts reported lower average dose (6.1 mg/kg/day) than those using purified CBD …

New Oklahoma City ordinance reduces penalty for marijuana possession!

Ask your state lawmakers to take this reform to the state level.

Starting on October 26, Oklahoma City’s maximum penalty for simple possession of marijuana will be reduced to a fine of up to $400. The Oklahoma City Council approved the proposal to remove jail time and reduce the penalty for marijuana possession last week. Until the new law takes effect, the maximum fine for possession is $1,200 and six months of jail time.

If you live in Oklahoma, let your lawmakers know the time has come for statewide decriminalization!

Penalizing individuals with jail time and a criminal record for possessing small amounts of marijuana wastes law enforcement resources. It can also lead to a lifetime of harsh consequences, including denial of student financial aid, housing, employment, and professional licenses. You can find more information on decriminalization here.

Please spread the word!

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Penn. legalization and regulation bill has been introduced!

Ask your legislators to end marijuana prohibition in Pennsylvania!

The drum beat for sensible marijuana policy is picking up in Pennsylvania!

Last Monday, Rep. Jake Wheatley introduced a bill that would legalize marijuana for adults 21 or older. This bill would also expunge the records of people who have been convicted of certain cannabis offenses.

If you are a Pennsylvania residentemail your state legislators today urging them to support HB 2600!

Ending marijuana prohibition would let adults make their own decisions about a substance that is safer than alcohol. Earlier this year, Auditor General Eugene DePasquale released a report estimating that legalization could generate more than $580 million in tax revenue for the state.

In other exciting news, on Tuesday Lancaster City Council decriminalized simple possession and use of marijuana! Possession of marijuana or related paraphernalia will be now be classified as a summary offense – carrying a fine or community service – rather than a misdemeanor.

Please spread the word so that together, we can end prohibition in the Keystone State.

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Register to vote and make your voice heard!

Click here for help registering in your state.

Election Day may not be until Tuesday, November 6, but in many states voter registration deadlines are coming up soon! MPP has teamed up with non-profit Rock the Vote to make it easier for our subscribers to register in their state. Just click here, and their simple tool will help you fill out the voter registration form in your state or tell you where to register online, if your state allows that.

After you fill out their form online, you’ll get an email with your official registration form attached, and all you have to do is print it and mail it in! Easy. Can’t make it to the polls on Election Day? You can also click here if you want to learn more about voting policies in your state, like early voting or voting by mail, as well as whether you can vote if you have a prior conviction.

Voters in Utah, Michigan, North Dakota, and Missouri will get to vote on marijuana initiatives this year, and MPP or our coalition partners have released voter guides in New Hampshire and Maryland. Click here to learn more, and please get out and vote!

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California Marijuana Laws 2018

California Marijuana Laws 2018

California Marijuana Laws 2018

California marijuana laws have changed drastically over the past few years. In 2016, voters approved Proposition 64. This legalized marijuana for everyone 21 and older. This includes allowing marijuana to be possessed, cultivated and also purchased. The passage of this law came 20 years after California became the first state to legalize medical marijuana in 1996.

Here is an overview of California marijuana laws:

 

Recreational marijuana:

  • It’s legal for those 21 and older to possess up to an ounce of marijuana, as well as up to eight grams of marijuana concentrates.
  • It’s legal for those 21 and older to grow up to six marijuana plants.
  • Possessing as well as growing marijuana for those under 21 is an infraction.

 

Medical marijuana:

  • Possessing up to eight ounces of marijuana, as well as up to eight grams of marijuana concentrates, is legal for patients.
  • Growing up to six mature, as well as 12 immature marijuana plants, is legal for patients.
  • When purchasing marijuana patients are exempt from the state sales tax.

 

Marijuana distribution:

  • Distributing marijuana is legal for businesses with a license from the state as well as their locality.
  • Marijuana retail outlets can sell up to an ounce of marijuana and up to eight grams of marijuana concentrates such as oils.
  • Selling marijuana without a license  is illegal.

 

Related Statutes:

  • Business & Professions Code Sections 26000, et seq, as well as;
  • Health & Safety Code Sections 11000, et seq.; 11357, et seq.; 11362.7, et seq.

 

Proposition 64:

Proposition 64 legalized marijuana. Its approval took place in November, 2016. Fifty seven percent voted in favor of the initiative. Parts of the law took effect immediately, with other parts taking effect over the following several months.

The full text of Proposition 64 can be found by clicking here.

 

In 1996 Proposition 215 passed in California with roughly 56% support. The initiative …

CBD May Help Treat Methamphetamine Dependency, States New Study

Cannabidiol (CBD) can “reduce the motivation to seek and consume methamphetamine”, suggesting it may be effective as a treatment for those addicted to the drug, finds a new study published by the Journal of Psychopharmacology.

“Methamphetamine is an addictive stimulant that can cause many adverse physical, psychological and psychosocial effects”, begins the study’s abstract. “Preliminary evidence shows cannabidiol, a non-intoxicating constituent of the cannabis plant, may have efficacy in treating opioid and nicotine dependence. However, no study has yet examined whether cannabidiol treatment might impact on methamphetamine addiction.”

The current study “investigated whether cannabidiol administration reduces the motivation to self-administer methamphetamine and relapse to methamphetamine-seeking behavior following abstinence.”

Thirty-two male Sprague Dawley rats with implanted jugular vein catheters were initially trained to self-administer methamphetamine via lever press during two-hour sessions on a fixed ratio 1 schedule of reinforcement. Rats in experiment 1 ( n=16) then advanced to a progressive ratio reinforcement schedule to examine the effects of cannabidiol (0, 20, 40, and 80 mg/kg intraperitoneal) on motivation to self-administer methamphetamine. Rats in experiment 2 ( n=16) were tested for cannabidiol effects on methamphetamine-primed reinstatement following extinction.

“Cannabidiol (80 mg/kg, but not 40 mg/kg, or 20 mg/kg) reduced the motivation to self-administer methamphetamine and attenuated methamphetamine-primed relapse to methamphetamine-seeking behavior after extinction”, states the study.

According to researchers,. this is the first demonstration “that cannabidiol can reduce the motivation to seek and consume methamphetamine, and suggests that cannabidiol might be worth trialing as a novel pharmacotherapy for methamphetamine dependence.”

The full study, conducted by researchers at Macquarie University and the University of Syndey, can be found by clicking here.

The post CBD May Help Treat Methamphetamine Dependency, States New Study appeared first on TheJointBlog.

from https://thejointblog.com/cbd-may-help-treat-methamphetamine-dependency-states-new-study/…

Here is the Most Expensive Bong in the World

The most expensive bong in the world (pictured below) is available now for just $1 million!

The website selling The Throne states that it’s considered to be “one of the most iconic and legendary functional glass pieces in the industry”. Standing nearly two feet tall, the piece was constructed in 2010. The skulls were made by Scott Deppe, and remove from the top to reveal the mouthpiece. The structure was assembled by Darby Holm using the Deppe’s Darkness color.” Banjo, the third collaborator, “constructed the one foot tall goddess that sits upon Darby’s lattice of bones.”

The airflow of this piece “begins at the push bowl, where it travels down into a large natural percolator and then on up the skeletal backbone to the mouthpiece.” Since this piece was first exhibited, “there have been several similar pieces created, but this one will always be considered the true original.”

The Throne can be viewed at Illuzion Glass Galleries in Denver, Colorado, and can be purchased online by clicking here.

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Study: Cannabis Oil Reduces Seizures, Improves Quality of Life, in Those with Dravet Syndrome

According to a new study, cannabis oil (containing both CBD and THC) is effective in reducing seizure counts and improving quality of life measures in those with Dravet Syndrome.

An epilepsy word cloud.

The study, titled A prospective open-label trial of a CBD/THC cannabis oil in dravet syndrome, was published by the journal Annals of Clinical and Translational Neurology.  According to the Dravet Foundation, dravet syndrome, also known as Severe Myoclonic Epilepsy of Infancy (SMEI), “is a rare and catastrophic form of intractable epilepsy that begins in infancy”, with “an estimated incidence rate of 1:16,000 to 1:21,000”.

The study’s abstract starts by stating that “Both Δ9 Tetrahydrocannabidiol (THC) and cannabidiol (CBD) components of cannabis, have been shown to have anticonvulsant effects. Cannabis oils are used to treat seizures in drug-resistant epilepsy (DRE).” It then goes on to note that “Recent trials provide data on dosing, side effects, and efficacy of CBD, yet there is a paucity of information on THC in epilepsy.”

The primary objective of the study “was to establish dosing and tolerability of TIL-TC150 – a cannabis plant extract produced by Tilray®, containing 100 mg/mL CBD and 2 mg/mL THC- in children with Dravet syndrome. Secondary objectives were to assess impact of therapy on seizures, electroencephalogram (EEG) and quality of life.”

For the study, twenty children “received add-on therapy with TIL-TC150. The dose ranged from 2 to 16 mg/kg/day of CBD and 0.04 to 0.32 mg/kg/day of THC. Patients were monitored for tolerability and adverse events, and secondary objectives.”

Nineteen participants completed the 20-week intervention. Mean dose achieved was 13.3 mg/kg/day of CBD (range 7-16 mg/kg/day) and 0.27 mg/kg/day of THC (range 0.14-0.32 mg/kg/day).

“There was a statistically significant improvement in quality of life, reduction in EEG spike activity, and median motor seizure reduction of 70.6%, with 50% responder rate of 63%”, states the study.

Researchers  conclude; “TIL-TC150 was safe and …

Medical Cannabis for Pets Bill Signed Into Law by California Governor

California Governor Jerry Brown has signed into law legislation that explicitly allows and regulates the medical use of cannabis for pets.

Assembly Bill 2215 was given approval by the full Senate in August by a vote of 37 to 1 vote, roughly three months after the Assembly passed it 60 to 10.  Governor Brown signed the measure into law yesterday.

Assembly Bill 2215 would expand “the intent of the Medicinal and Adult-Use Cannabis Regulation and Safety Act (MAUCRSA) to control and regulate cannabis and cannabis products for medicinal use on pets.” It would define “cannabis products” to include products intended for medicinal use on a pet, and although it wouldn’t allow a veterinarian to administer medical cannabis, it  would “allow a veterinarian to discuss the use of cannabis on an animal for medicinal purposes without being disciplined or denied, revoked or suspended by the Veterinary Medical Board (VMB).”

The measure states that the VMB “would have until July 1, 2019 to promulgate guidelines for veterinarians to follow when discussing the use of cannabis”, and it “Provides that a cannabis product for use on a pet may only be sold to an adult 21 years or age or over by a licensee who has been issued a retailer license, as specified.”

The full text of Assembly Bill 2215 can be found by clicking here.

The post Medical Cannabis for Pets Bill Signed Into Law by California Governor appeared first on TheJointBlog.

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The Top 15 Fun Things To Do While High | HonestMarijuana

Woman smoking weed & thinking about things to do while high

Being high is pretty damn great all by itself. But sometimes just sitting there stewing in your own psychedelic juices isn’t enough. You need something more. That’s when you start looking for fun things to do while high.

And while recreating the stunts from Jackass, making a backyard wrestling video, or taunting a badger is never a good idea, there are plenty of less dangerous activities that make being high even better than it already is.

Top 15 Fun Things To Do While High

1) Dance

Yes, gravity (and couch lock) can be rough, but you’ll enjoy your high more if you get up and move once in a while. Pick a type of music that gets your foot tapping, crank up the volume, and let your body move to the beat.

2) Tai Chi

Capitalize on your heightened awareness by learning and performing some Tai Chi. You’ll be more aware of your breathing, your heartbeat, and the flow of energy from head to toe and back again. That’ll make Tai Chi, and being high, more stimulating.

3) Hula Hoop

Hula-hooping as one of the things to do while high

We never could hula hoop sober. But after a few tokes on an Honest Blunt, we could damn near turn pro (if that were a thing…which it should be). There’s something extremely satisfying about finding the rhythm in your hips that keeps that hoop spinning.

Add in a bit of your favorite music, and the experience will be transcendent.

4) Go To The Circus

Sure, you probably got your fill of the circus when you were a kid, and now it’s nothing special. But the circus can be seriously mind-blowing again if you hit your bong first.

Don’t have a circus near you? Really, anything with a lot of movement and flashy colors will work (e.g., Cirque du Soleil, Stomp). And if you really have no other options, stick in The Greatest Showman and get your fix that way.…

Chart: The History of U.S. State Marijuana Ballot Initiatives


On the 2018 Ballot

Mormons Oppose Marijuana Initiative in Utah Despite History of Cannabis Use

Michigan Is Poised to Become the 10th State to Legalize It

Dueling Initiatives in Missouri Likely to Confuse Voters

Recreational Legalization on the North Dakota Ballot

If you enjoyed this Freedom Leaf article, subscribe to the magazine today!

The post Chart: The History of U.S. State Marijuana Ballot Initiatives appeared first on Freedom Leaf.

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Ask candidates for the Maryland Legislature to commit to supporting marijuana policy reform

The latest Goucher poll shows that 62% of Marylanders “support the legalization of marijuana for recreational use.” Unfortunately, Maryland’s lawmakers have lagged behind the public on this issue — but this could change in November’s election. If you are a Maryland voter,  please let the candidates in your district know that this issue is important to you. (And don’t forget to check out the Maryland Cannabis Policy Coalition’s Voter Guide here.)

If you are interested in hearing more about MPP’s work — and meeting our new executive director, Steven Hawkins — please consider attending the Spark! Maryland networking event on October 4 at 6:30 p.m. at The Reserve at Two Rivers, 4105 Mountain Road, Pasadena, MD 21122. You can purchase tickets here.

Marylanders are ready to join the eight other states that have legalized and regulated marijuana for adults 21 and older. Click here to ask the people who want to represent you in the General Assembly if they’re ready too.

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Rick Steves to tour Michigan in support of legalization ballot measure

Next week, legendary travel host Rick Steves will be visiting Michigan to give talks in support of Prop 1, the ballot initiative to legalize and regulate marijuana. Known for his hit PBS series “Rick Steves’ Europe,” Rick’s engaging personality and first-hand experience seeing the benefits of legalization in his home state of Washington make this an event you don’t want to miss.

You can catch him in two locations, Grand Rapids and Ann Arbor. Both speaking events are free and open to the public. The tour schedule is listed below.

TUESDAY, OCTOBER 2
It’s Time for a New Approach: Rick Steves on why legalization is a better solution
Time: 7:30 p.m., doors at 7:00 p.m.
Location: Peter Martin Wege Theatre, 341 Ellsworth Ave. SW, Grand Rapids
Cost: FREE
Register here

WEDNESDAY, OCTOBER 3
It’s Time for a New Approach: Rick Steves on why legalization is a better solution
Time: 8:30 p.m., doors at 8:00 p.m.
Location: Rackham Amphitheatre, 915 E Washington St., Ann Arbor
Cost: FREE
Register here

As a board member of NORML, Rick Steves has been a long-time advocate for sensible marijuana policies. Audiences around the country have heard his informative and entertaining talks on marijuana legalization, and now you have a chance to see him, too. Register for one of the events above and share the word by inviting friends and family.

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How Long Does Weed High Last: The Definitive Answer

Clocks telling how long does weed high last

If there’s one question that everyone seems to wonder about — but no one knows the answer to — it’s, “How long does weed high last?” If you’re new to the world of marijuana, don’t feel bad asking this question. Even many long-time cannaseurs have a hard time giving a conclusive answer.

But not us! We know what you want to hear. So in this article, the cannabis experts at Honest Marijuana give you the definitive answer to the question how long does weed high last.

How Long Does Weed High Last?

The best way to answer that question is by saying, “It depends…” We know that’s not very definitive, but let us finish. Before you get angry and storm off, the duration of your weed high really does depend on the way you consume your THC.

What that means is that you can tailor your experience by choosing from among the many different methods of getting THC into our body. Once you decide that, we can give you a much more definitive answer to your question.

Here’s how the durations break down based on method of consumption.

Smoking

Smoking is one of the most common ways to get your ganja on. The tools used for smoking are literally legion and include:

Basically, any time you inhale the smoke or vapor from a marijuana product, you’re smoking.

How long does a smoking weed high last? 1-3 hours

Edibles

Woman who's high on weed

There are so many ways to make your marijuana into edibles that you’re really only limited by your creativity. Our favorite edibles include:

Yes, that’s right. Milk, tea, and pills are included on this list. Basically, anything that you put in your mouth and swallow can be considered an edible.

How long does an edibles weed high last? 4-6 …

NY: Medical marijuana program adds acute pain management as qualifying condition

On Monday, September 24, Gov. Andrew Cuomo signed a bill that adds acute pain management to the list of approved conditions eligible for treatment with medical marijuana as an alternative to opioid use. This new law formalizes regulations the New York State Department of Health issued in July, which added opioid replacement and opioid use disorder to the list.

This is great news for patients! Access to medical marijuana is no longer limited to those suffering from chronic pain. This bill and regulations allow more patients who could benefit from medical marijuana a safe and effective alternative to highly addictive opioids.

Find more information on New York’s medical marijuana program, including the list of qualifying conditions and how to register, here.

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from https://blog.mpp.org/medical-marijuana/ny-medical-marijuana-program-adds-acute-pain-management-as-qualifying-condition/…

Study: Cannabinoids May Inhibit Tumor Growth in Triple Negative Breast Cancer

According to a new study published by the journal Photodiagnosis and Photodynamic Therapy, cannabinoids may inhibit tumor growth in triple negative breast cancer.

The study states that “Triple negative breast cancer (TNBC) is the deadliest form of breast cancer because compared with other types of breast cancer, it is more aggressive, diagnosed at later stage and more likely to develop recurrence”. Many patients “do not experience adequate tumor control after current clinical treatments involving surgical removal, chemotherapy and/or radiotherapy, leading to disease progression and significantly decreased quality of life.”

Here researchers “report a new combinatory therapy strategy involving cannabinoid-based medicine and photodynamic therapy (PDT) for the treatment of TNBC.” They found that “the combined CB2R agonist and TSPO-PDT treatment resulted in synergistic inhibition in TNBC cell and tumor growth.”

The study concludes; “This combinatory therapy approach provides new opportunities to treat TNBC with high efficacy. In addition, this study provides new evidence on the therapeutic potential of CB2R agonists for cancer.”

For the full study, click here.

The post Study: Cannabinoids May Inhibit Tumor Growth in Triple Negative Breast Cancer appeared first on TheJointBlog.

from https://thejointblog.com/study-cannabinoids-may-inhibit-tumor-growth-in-triple-negative-breast-cancer/…

New York Governor Signs Bill Adding Pain Management to List of Medical Cannabis Conditions

Governor Andrew Cuomo yesterday signed legislation (S8987A/A 11011-B) that adds acute pain management to the list of conditions for which medical marijuana can be recommended as an alternative to opioid use.

The bill will also allow for substance use disorder treatment providers to recommend medical marijuana to help patients manage underlying pain that contributes to the abuse of substances such as opioids.

“In this battle against the opioid epidemic, it is critical that we use every means at our disposal to prevent the unnecessary prescription of these dangerous and addictive painkillers,” Governor Cuomo said. “Adding these conditions to the list of those approved for management with medical marijuana will help reduce the risk of addiction and provide suffering New Yorkers the relief they need.”

“We know that medical marijuana can be a helpful alternative for a wide range of illnesses and conditions,” said Lieutenant Governor Kathy Hochul. “By expanding the approved list, we are providing New Yorkers with new options, and preventing the danger that comes from opioid addiction.”

The bill will formalize into law the regulatory change that was implemented by the Department of Health earlier this year that added opioid replacement and opioid use disorder to the existing list of conditions for which a patient can qualify for medical marijuana. In order to recommend medical marijuana for pain management, a registered practitioner must determine that the patient’s pain degrades health and functional capability, along with certain other requirements.

Senator George Amedore, Chairman of the Senate Standing Committee on Alcoholism and Substance Abuse said, “As the Senate Task Force on Heroin and Opioid Addiction travelled the state, this was a big gap that we heard about over and over. When we look at solutions to help us combat the heroin and opioid epidemic, we must ensure prescribers and patients have every resource and option at their disposal. I’m glad the Governor has signed this legislation that will help patients …

Mormons Oppose Marijuana Initiative in Utah Despite History of Cannabis Use

Mormons with Mexicans in Northern Mexico, 1908

In 1885, the prophet and president of the Mormon Church, John Taylor, purchased about 100,000 acres of land in Mexico—in Chihuahua and Sonora, to be exact, some 200 miles south of the US border. More than 300 polygamous Mormon families from Utah migrated south to settle the land and to proselytize (even today you see the traveling twosomes of fresh-faced young men in their white shirts, ties and black name tags) and, many theorize, to preserve the practice of polygamy.

At the time, Mormon polygamists were being jailed and having their property seized. Utah itself was denied statehood by the federal government to halt the practice. Former presidential candidate Mitt Romney is descended from the Mexican settlements; his father, George, and grandfather, Marion, were born in Colonia Dublán, Mexico, in 1907.

But in 1910, many who had settled in northern Mexico began an exodus back to Utah due to anti-American sentiment fueled by the Mexican Revolution. Some say they returned with a local plant introduced by the natives: cannabis.

The Mormon Church, formally known as the Church of Jesus Christ of Latter-Day Saints (LDS), were and still are infamous for their teetotaler ways and as abstainers of vices of all kinds; hence, they didn’t look kindly on the brethren partaking of the plant, viewing it as a violation of Mormon scripture from the “Doctrine and Covenants,” section 89 (D&C 89), commonly referred to as the “Word of Wisdom.”

Michigan legalization campaign wins a big endorsement

Great news! The Detroit Free Press, one of Michigan’s largest media outlets, has endorsed the Yes on 1 legalization campaign!

The paper’s supportive editorial echoed many of the Yes on 1 campaign’s core messages: marijuana prohibition wastes law enforcement resources, unfairly harms communities of color, and prevents the state from collecting millions in tax revenue that could fund critical social programs. This is a huge boost for Prop 1, but we have to make sure the momentum is carried forward into November.

You can help the Yes on 1 team by making a donation here. Supporters can also promote the effort by picking up Yes on 1 gear from the new campaign store. There, you’ll find some great items, including t-shirts, hoodies, and yard signs, with the official Yes on 1 logo.

We’re just a few weeks away from Election Day (November 6). Michigan residents should visit the Secretary of State’s voter page to get information about polling locations, absentee voting, and more. The deadline to register to vote is October 9. If you’re not already registered, click here for the registration form. Be sure to fill it out and deliver it to your city or town clerk’s office by October 9.

If you have friends or family in Michigan, please forward this email to them and ask them to vote “Yes” on Prop 1. I’m confident that if enough people pitch in, we’ll be celebrating another major victory on November 6.

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Study: CBD Could Prevent Haloperidol-Induced Orofacial Dyskinesia

Cannabidiol (CBD) may prevent haloperidol-induced orofacial dyskinesia, according  to new research being published by the journal Brain, Behavior, and Immunity; the research was epublished by the National Institute of Health.

“The chronic use of drugs that reduce the dopaminergic neurotransmission can cause a hyperkinetic movement disorder called tardive dyskinesia (TD)”, states the study’s abstract. “The pathophysiology of this disorder is not entirely understood but could involve oxidative and neuroinflammatory mechanisms. Cannabidiol (CBD), the major non-psychotomimetic compound present in Cannabis sativa plant, could be a possible therapeutic alternative for TD.”

The study states that “This phytocannabinoid shows antioxidant, anti-inflammatory and antipsychotic properties and decreases the acute motor effects of classical antipsychotics. The present study investigated if CBD would attenuate orofacial dyskinesia, oxidative stress and inflammatory changes induced by chronic administration of haloperidol in mice.”

Furthermore, researchers “verified in vivo and in vitro (in primary microglial culture) whether these effects would be mediated by PPARγ receptors. The results showed that the male Swiss mice treated daily for 21 days with haloperidol develop orofacial dyskinesia. Daily CBD administration before each haloperidol injection prevented this effect.”

Mice treated with haloperidol “showed an increase in microglial activation and inflammatory mediators in the striatum. These changes were also reduced by CBD. ”

The study concludes by stating that; “In conclusion, our results suggest that CBD could prevent haloperidol-induced orofacial dyskinesia by activating PPARγ receptors and attenuating neuroinflammatory changes in the striatum.”

For the full study, click here.

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